2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-12242A
    GBR 12935 76778-22-8 98%
    GBR 12935 is a potent, and selective dopamine reuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 also prevents the d-Fenfluramine-induced head-twitch response in mice.
    GBR 12935
  • HY-122508
    Hydroxyebastine 210686-41-2
    Hydroxyebastine is an Ebastine (HY-B0674) (a histamine H1-receptor antagonist) metabolite. Hydroxyebastine is metabolized to Carebastine (HY-121356) by CYP2J2 and CYP3A4.
    Hydroxyebastine
  • HY-123744
    PD-156707 162412-70-6 99.92%
    PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist. PD-156707 binds to human ET-A and ET-B receptors with Ki values of 0.17 nM and 133.8 nM, respectively. PD-156707 shows reversal of established chronic hypoxic pulmonary hypertension in rats. PD-156707 can be used for the study of diseases associated with abnormal ET-A receptor activation, particularly pulmonary hypertension, stroke, and heart failure.
    PD-156707
  • HY-124744
    ASP 8477 906737-25-5 98.35%
    ASP 8477 is an orally active and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 values ​​of 3.99, 1.65, and 57.3 nM for human FAAH-1, FAAH-1 (P129T), and FAAH-2, respectively. ASP 8477 has central nervous system activity and can be used in analgesia research.
    ASP 8477
  • HY-126765
    Territrem B 70407-20-4
    Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus.
    Territrem B
  • HY-12721R
    Clonidine (Standard) 4205-90-7 99.66%
    Clonidine (Standard) is the analytical standard of Clonidine. This product is intended for research and analytical applications. Clonidine is an alpha 2-adrenergic agonist.
    Clonidine (Standard)
  • HY-129771
    3-BMC hydrochloride 676487-42-6 99.9%
    3-Bromomethcathinone (3-BMC) hydrochloride is a drug derivative.
    3-BMC hydrochloride
  • HY-129899
    (±)-Equol 4'-sulfate sodium 1189685-28-6 ≥99.0%
    (±)-Equol 4'-sulfate sodium is a metabolite of the isoflavonoid phytoestrogen (±)-Equol (HY-100583A) .
    (±)-Equol 4'-sulfate sodium
  • HY-130394
    2C-B-FLY hydrochloride 178557-21-6 99.9%
    2C-B-FLY hydrochloride is the dihydrodifuran analog of the Schedule I hallucinogen 4-bromo-2,5-dimethoxyphenethylamine (2C-B).
    2C-B-FLY hydrochloride
  • HY-13059A
    SDZ 220-581 Ammonium salt 179411-94-0 98.61%
    SDZ 220-581 Ammonium salt is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.
    SDZ 220-581 Ammonium salt
  • HY-13059B
    SDZ 220-581 hydrochloride 179411-93-9 99.48%
    SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.
    SDZ 220-581 hydrochloride
  • HY-13225A
    Rivanicline 15585-43-0 98%
    Rivanicline (RJR-2403) is a neuronal nicotinic receptor agonist. Rivanicline is highly selective for the rat brain cortex nAChRs (Ki = 26 nM, EC50 of 732 nM) and α4β2 subtype (Ki = 26 nM, EC50 = 16 μM). Rivanicline can significantly restore the learning impairment and cognitive dysfunction. Rivanicline can be used for the study of neurodegenerative diseases (such as schizophrenia or Alzheimer's disease).
    Rivanicline
  • HY-133086
    Hydrodolasetron 127951-99-9 98.96%
    Hydrodolasetron is a metabolite of Dolasetron (HY-B0750). Hydrodolasetron is more potent than Dolasetron in inhibiting nAChR. Hydrodolasetron is a 5-HT(3A)R blocker with an IC50 of 0.29 nM. Hydrodolasetron has antiemetic activity.
    Hydrodolasetron
  • HY-134137
    Donepezil N-oxide 120013-84-5 99.9%
    Donepezil N-oxide, a metabolite of Donepezil (HY-14566), is human erythrocyte acetylcholinesterase (AChE) inhibitor.
    Donepezil N-oxide
  • HY-134345
    8-pCPT-cGMP-AM 272445-72-4 98%
    8-pCPT-cGMP-AM (8-(4-Chlorophenylthio)-cGMP-AM) is a highly membrane permeable prodrug of the PKG agonist 8-pCPT-cGMP, which increases the membrane permeability of cGMP and is converted to its active form by esterase hydrolysis within the cell, thereby activating PKG. 8-pCPT-cGMP-AM can be used to explore the role of cGMP signaling in neural plasticity and memory formation.
    8-pCPT-cGMP-AM
  • HY-134358
    Ara-F-NAD+ 133575-27-6 98%
    Ara-F-NAD+ is an arabino analogue of NAD+. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor.
    Ara-F-NAD+
  • HY-134555
    A3AR antagonist 4 109740-09-2 99.98%
    A3AR antagonist 4 (Compd 1) is an A3AR antagonist, with Ki values of 30.8 nM (hA3) and 203 nM (hA1), repectively. A3AR antagonist 4 (Compd 1) can be used for the study of cerebral ischemia.
    A3AR antagonist 4
  • HY-135237
    DB04760 analog 1 2728373-94-0 99.87%
    DB04760 analog 1 is an analogue of DB04760.
    DB04760 analog 1
  • HY-138176
    7-Hydroxyrisperidone 147663-04-5 98%
    7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone (HY-11018). Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist.
    7-Hydroxyrisperidone
  • HY-138289
    4-acetoxy MPT 2173386-55-3 98.8%
    4-acetoxy MPT is a tryptamine that induces the head-twitch response (HTR) in mice.
    4-acetoxy MPT
Cat. No. Product Name / Synonyms Application Reactivity